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10.442 / 10.542 Biochemical Engineering

Spring 2005

Bioreactor used in the production of drugs.Bioreactors like the one pictured here are used in the production of drugs by purifying them using microscopic spheres that serve as sophisticated filters. (Photo by Bio-Rad Laboratories, courtesy of the National Science Foundation.)

Course Highlights

This course features a complete set of assignments, an extensive list of readings, and a sample of study materials.

Course Description

This course focuses on the interaction of chemical engineering, biochemistry, and microbiology. Mathematical representations of microbial systems are featured among lecture topics. Kinetics of growth, death, and metabolism are also covered. Continuous fermentation, agitation, mass transfer, and scale-up in fermentation systems, and enzyme technology round out the subject material.



Syllabus

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Required Text

Amazon logo Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.

We will also use published articles from peer-reviewed scientific literature. You may find the following texts to be useful as additional resources:

Amazon logo Blanch, Harvey W., and D. S. Clark, eds. Biochemical Engineering. New York, NY: Marcel Dekker Incorporated, 1997. ISBN: 9780824700997.

Amazon logo Bailey, James E., and David F. Ollis. Biochemical Engineering Fundamentals. New York, NY: McGraw-Hill Education, 1986. ISBN: 9780070666016.



Grading

Students are encouraged to work with classmates outside of lecture periods and discuss the course and course assignments; however, final solutions to homework problems are to be prepared on an individual basis. The penalty for cheating will be a "zero" grade for all parties involved.


ACTIVITIESPERCENTAGES
Four In-class Quizzes80%
Problem Sets15%
Class Participation5%




Calendar

SES #TOPICSKEY DATES
1Course Overview, Enzyme Classification
2Enzyme Kinetics (Single-substrate Reactions), Measurement
3Enzyme Inhibition
4Enzyme Inhibition, pH and Temp Effects
5Non-ideal Enzyme KineticsProblem set 1 due
6Immobilized Enzyme Kinetics - External
7Immobilized Enzyme Kinetics - Internal
8Applications of Enzyme Catalysis (Biocatalysis)Problem set 2 due
9Microbial Growth
10Microbial Growth - Batch Cultivation Profiles
Quiz 1
11Stoichiometry of Growth, Product Formation
12Stoichiometry of Growth, Product Formation (cont.)
13Models of Microbial GrowthProblem set 3 due
14Models of Microbial Growth (cont.)
15Continuous Culture
16Continuous Culture (cont.)Problem set 4 due
17Bioreactor Design
18Bioreactor Design (cont.)
Quiz 2
19Bioreactor Design (cont.)
20Mass Transfer
21Mass Transfer (cont.)
22Heat Transfer, Media and Air Sterilization
23Scale-up
24Scale-downProblem set 5 due
25Animal Cell Culture
26Animal Cell Culture (cont.)
Quiz 3
27Mixed Cultures
28Mixed Cultures (cont.)
29Medium Development
30Medium Development (cont.)
31Cellular Engineering - An Engineer's View Towards Recombinant OrganismsProblem set 6 due
32Cellular Engineering/Molecular Biology for Process Engineering
33Cellular Engineering/Molecular Biology for Process Engineering (cont.)
34Enzyme Engineering for Process Improvement
35Enzyme Engineering for Process Improvement (cont.)
Quiz 4




Readings

Amazon logo Help support MIT OpenCourseWare by shopping at Amazon.com! MIT OpenCourseWare offers direct links to Amazon.com to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from Amazon.com, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses.


Required Text

[S&K] Amazon logo Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.



Additional Resources

Amazon logo Blanch, Harvey W., and D. S. Clark, eds. Biochemical Engineering. New York, NY: Marcel Dekker Incorporated, 1997. ISBN: 9780824700997.

Amazon logo Bailey, James E., and David F. Ollis. Biochemical Engineering Fundamentals. New York, NY: McGraw-Hill Education, 1986. ISBN: 9780070666016.

Rozzell, J. D. "Commercial scale biocatalysis: myths and realities." Bioorg Med Chem 7, no. 10 (October 1999): 2253-61.


SES #TOPICSREADINGS
1Course Overview, Enzyme ClassificationS&K. Chapter 1.
2Enzyme Kinetics (Single-substrate Reactions), MeasurementS&K. Chapter 3.1-3.3.3.
3Enzyme InhibitionS&K. Chapter 3.3.4.
4Enzyme Inhibition, pH and Temp EffectsS&K. Chapter 3.3.5.
5Non-ideal Enzyme KineticsClass notes
6Immobilized Enzyme Kinetics - ExternalS&K. Chapter 3.4.
7Immobilized Enzyme Kinetics - InternalS&K. Chapter 3.4.
8Applications of Enzyme Catalysis (Biocatalysis)S&K. Chapter 3.5, 3.6.

Handouts
9Microbial GrowthS&K. Chapter 6.1-6.2.
10Microbial Growth - Batch Cultivation ProfilesS&K. Chapter 6.1-6.2.
11Stoichiometry of Growth, Product FormationS&K. Chapter 7.
12Stoichiometry of Growth, Product Formation (cont.)S&K. Chapter 7.
13Models of Microbial GrowthS&K. Chapter 6.3.
14Models of Microbial Growth (cont.)S&K. Chapter 6.3.
15Continuous CultureS&K. Chapter 6.4.
16Continuous Culture (cont.)S&K. Chapter 6.4.
17Bioreactor DesignS&K. Chapter 9.1-9.3.
18Bioreactor Design (cont.)S&K. Chapter 9.1-9.3.
19Bioreactor Design (cont.)
20Mass TransferS&K. Chapter 6.2.3-6.2.4, 10.2.3.
21Mass Transfer (cont.)S&K. Chapter 6.2.3-6.2.4, 10.2.3.
22Heat Transfer, Media and Air SterilizationS&K. Chapter 10.4.
23Scale-upS&K. Chapter 10.2.4.
24Scale-downS&K. Chapter 10.2.5.
25Animal Cell CultureS&K. Chapter 12.
26Animal Cell Culture (cont.)S&K. Chapter 12.
27Mixed CulturesS&K. Chapter 16.
28Mixed Cultures (cont.)S&K. Chapter 16.
29Medium DevelopmentHandouts
30Medium Development (cont.)Handouts
31Cellular Engineering - An Engineer's View Towards Recombinant OrganismsS&K. Chapter 14.

Handouts
32Cellular Engineering/Molecular Biology for Process EngineeringS&K. Chapter 14.

Handouts
33Cellular Engineering/Molecular Biology for Process Engineering (cont.)S&K. Chapter 14.

Handouts
34Enzyme Engineering for Process ImprovementHandouts
35Enzyme Engineering for Process Improvement (cont.)Handouts




Assignments

Amazon logo Help support MIT OpenCourseWare by shopping at Amazon.com! MIT OpenCourseWare offers direct links to Amazon.com to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from Amazon.com, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses.

Several problems are from the required text:

Amazon logo Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.

Problem Set 1 (PDF)

Problem Set 2 (PDF)

Problem Set 3 (PDF)

Problem Set 4 (PDF)

Problem Set 5 (PDF)





Study Materials

Amazon logo Help support MIT OpenCourseWare by shopping at Amazon.com! MIT OpenCourseWare offers direct links to Amazon.com to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from Amazon.com, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses.


Exam Practice Problems

Several problems are from the required text:

Amazon logo Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.

Practice Problems for Quiz 1 (PDF)

Practice Problems for Quiz 2 (PDF)

Practice Problems for Quiz 3 (PDF)



Handouts

The following materials on enzyme processes were handed out during class:

Enzyme Nomenclature (PDF)

Example EC Reactions (PDF)

Biocatalysis Class Notes (PDF)

Survey of Biocatalytic Reactions (PDF)




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