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測驗


本頁翻譯進度

燈號說明

審定:邱富敏(簡介並寄信)
翻譯:溫榮弘(簡介並寄信)
編輯:汪仁傑(簡介並寄信)

此期中測驗佔課程最後總成績的30%


在家作答的期中測驗

請回答下列問題(每題10分)。

1. 水在不同溫度所具有的不同結構?為何水的結構對蛋白質次級結構與蛋白質-蛋白質間的交互作用是具有重要性的?水合作用對維持蛋白質的溶解度具有重要性。如何達到的呢?

2. 請繪出20個左旋氨基酸與4個核苷酸的結構。請寫下它們的全名、三字母碼與單字母碼。請依據氨基酸支鏈的本質來分類:疏水性、親水性、極性與非極性。請簡短解釋每一「類」與水的交互作用的傾向。請繪出帶電氫鍵的形成,並解釋它們如何與水作用。請繪出核苷酸基的所有可能氫鍵。

3. 請描述下列次級結構的基本特性。並解釋它們在決定蛋白質與蛋白質材料結構上的功能。

a. 阿爾發螺旋
b. 310螺旋
c. p螺旋
d. 貝它螺旋
e. 貝它褶板
f. 旋轉數與迴圈數
g. 膠原蛋白螺旋

4. 請詳細描述胜肽鍵的形成與其結構。你可以推論其它結構的形成是基於胜肽鍵結構嗎?

5. 卷曲螺旋的特性為何?請描述二股、三股與四股的卷曲螺旋。在自然界中何處可以發現這樣的卷曲螺旋?

6.請解釋膠原蛋白的高解析度結晶結構的重要性。我們從結晶結構中可以學到什麼?請解釋為何氨基乙酸與脯氨酸對膠原蛋白結構的形成是很重要的?膠原蛋白如何進行自我組裝?

7.請描述蠶絲與蜘蛛絲的分子結構。這二種蛋白質均含有大量的氨基乙酸。這些氨基乙酸分子基是如何在絲狀結構中排列?

8. 請簡短地解釋用在決定生物材料的分子結構上的X光結晶學。請簡短地解釋用在決定生物材料分子結構上的核磁共振。

9.請描述自然界如何製造不同型態的生物源礦物。

10. 利用你在課堂上所學習的知識來設計一個有趣的建構主模(提示:利用不同的重覆序列)。

X. 另外的選擇:你可以利用下面的方式來取代上面(1-9)中的一個問題:

詢問一個我們在課堂上所包括的相關材料中你所認為是一個重點的問題。然後簡短地回答你的問題。




This mid-term exam constitutes 30% of the final grade for the course.


Take-home Midterm Exam

Please answer each of the questions (10 points each).

1. What is the structure of water at different temperatures? Why is the structure of water important in the formation of protein secondary structures and protein-protein interactions? Hydration is important for maintaining a protein soluble. How?

2. Please draw the structures of 20 L-amino acids and 4 nucleotides. Write their full names, three-letter code and one letter code. Please group amino acids according to the nature of their side chains: hydrophobic, hydrophilic, polar and nonpolar. Explain briefly each group’s tendency to interact with water. Please draw the potential hydrogen bond formations and explain how they interact with water. Draw all possible hydrogen bonds for the nucleic acid bases.

3. Describe the basic characteristic of the following secondary structures. Also, explain their function in determining the structures of protein and protein-materials.

a. alpha-helix
b. 310 helix
c. p helix
d. beta-helix
e. beta-sheet
f. turns and loops
g. collagen helix

4. Describe peptide bond formation and its structure in great detail. Can you deduce other structure formations based on the peptide bond structure?

5. What is characteristic of coiled-coils? Describe two, three and four strands of coiled coils. Where do you find such coiled coils in nature?

6. Explain the significance of the high-resolution crystal structure of collagen. What have we learned from the crystal structure? Explain why glycines and prolines are important in forming structure of collagen? How do collagens undergo self-assembly?

7. Describe the molecular structures of silkworm silk and the spider silk. Both proteins have high content of glycine. How are these glycine residues arranged in the silk structures?

8. Briefly explain the tool of X-ray crystallography used in determination of the molecular structure of biological materials. Briefly explain the tool of NMR in determination of the molecular structure of biological materials.

9. Describe how nature makes various types of biominerals.

10. Using the knowledge you have learned in the class to design an interesting building structural motif (hint: use various repeating sequences).

X. Alternative: You may replace a question above (1-9) with the following:

Ask a question related to the material we have covered in class that you think probes an important point. Then answer your question briefly.




 
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