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Readings (PDF)

Recommended Readings

Although the lecture notes represent the only required reading material for this course, time constraints prohibit a comprehensive coverage of all essential topics in gastroenterology. You are therefore highly encouraged to supplement your reading during the course by the following two resources:

"The Gastrointestinal Tract" (chap. 18), "Liver and the Biliary Tract" (chap. 19), and "The Pancreas" (chap. 20) in Robbins Pathological Basis of Diseases. 6th ed. W. B. Saunders Co., 1998. (Countway Course Reserve).

Gastroenterology, Saunders Text and Review Series. W. B. Saunders Co., 1997. (Countway Course Reserve).

Both of the above resources are well-written and concise, and include high-quality photographs and radiographs of classical gastrointestinal diseases. In addition to the above basic reading material, you may want to browse the following comprehensive texts and keep them in mind for future reference:

Histology and Pathology:

Chandrasoma, P. Gastrointestinal Pathology. Stamford, Conn.: Appleton & Lange, 1999.

Fawcett, D. W., and W. Bloom. et al. A Textbook of Histology. New York: Chapman & Hall, 1997.

Fenoglio-Preiser, C. M. Gastrointestinal Pathology: An Atlas and Text. Philadelphia: Lippincott-Raven, 1999.

Ming, S. C., and H. Goldman. Pathology of the Gastrointestinal Tract. Baltimore: Williams & Wilkins, 1998.

MacSween, R. N. M. Pathology of the Liver. Edinburgh, New York: Churchill Livingstone, 2001.

Clinical Gastroenterology and Hepatology:

Gore, R. M., and M. S. Levine. Textbook of Gastrointestinal Radiography. Philadelphia: W. B. Saunders, 2000.

Schiff, E. R., and M. F. Sorrell. et al. Schiff's Diseases of the Liver. Philadelphia: Lippincott-Raven Publishers, 1998.

Sherlock, S., and J. Dooley. Diseases of the Liver and Biliary System. Oxford, Malden, Mass.: Blackwell Science, 2001.

Feldman, M., B. and Scharschmidt. et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 7th ed. Philadelphia, Pa.: Saunders, 2002.

Tahara, E. Molecular Pathology of Gastroenterological Cancer: Application to Clinical Practice. Tokyo; New York: Springer, 1997.

Zakim, D., and Boyer T. Hepatology: A Textbook of Liver Disease. 4th ed. Philadelphia: W. B. Saunders, 2002.



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Nervi, F. "Significance of Biliary Phospholipids for Maintenance of the Gastrointestinal Mucosal Barrier and Hepatocellular Integrity [editorial]". Gastroenterology 118, 6 (2000): 1265-7.

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Neutra, M. R. "M Cells in Antigen Sampling in Mucosal Tissues." Curr Top Microbiol Immunol 236 (1999): 17-32.

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Sansonetti, P. J., and A. Phalipon. "M Cells as Ports of Entry for Enteroinvasive Pathogens: Mechanisms of Interaction, Consequences for the Disease Process." Semin Immunol 11, 3 (1999): 193-203.

Borghesi, C., M. J. Taussig, and C. Nicoletti. "Rapid Appearance of M Cells After Microbial Challenge is Restricted at the Periphery of the Follicle-associated Epithelium of Peyer's Patch." Lab Invest 79, 11 (1999): 1393-401.

Janin, N. "A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability." Adv Cancer Res 77 (2000): 189-221.

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Tomlinson, I. "Different Pathways of Colorectal Carcinogenesis and their Clinical Pictures." Ann N Y Acad Sci 910 (2000): 10-8; discussion 18-20.

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Karnes, W. E., Jr. "Implications of Low COX-2 Expression in Colorectal Neoplasms with Defective DNA Mismatch Repair." J Cell Biochem 77, S34 (2000): 23-27.

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Lipkin, S. M. et al. "MLH3: A DNA Mismatch Repair Gene Associated with Mammalian Microsatellite Instability." Nat Genet 24, 1 (2000): 27-35.

Lino, H. et al. "DNA Microsatellite Instability and Mismatch Repair Protein Loss in Adenomas Presenting in Hereditary Non-Polyposis Colorectal Cancer." Gut 47, 1 (2000): 37-42.

Morteau, O. et al. "Impaired Mucosal Defense to Acute Colonic Injury in Mice Lacking Cyclooxygenase-l or Cyclooxygenase-2." J Clin Invest 105, 4 (2000): 469-78.

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Mylonas, P. G. et al. "Growth Hormone and Insulin-like Growth Factor I Protect Intestinal Cells Nom Radiation Induced Apoptosis." Mol Cell Endocrinol 160, 1-2 (2000): 115-22.

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Gewirtz, A. T. et al. "Salmonella Typhimurium Induces Epithelial IL-8 Expression via Ca(2+)-mediated Activation of the NF-kappaB Pathway." J Clin Invest 105, 1 (2000): 79-92.

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Wessler, S. et al. "Helicobacter Pylori Activates the Histidine Decarboxylase Promoter Through a Mitogenactivated Protein Kinase Pathway Independent of Pathogenicity Island-encoded Virulence Factors." J Bioi Chem 275, 5 (2000): 3629-36.

Rasko, D. A. et al. "Cloning and Characterization of the Alpha (1,3/4) Fucosyltransferase of Helicobacter Pylori." J Bioi Chem 275, 7 (2000): 4988-94.

Donahue, J. P. et al. "Analysis of iceA 1 Transcription in Helicobacter Pylori." Helicobacter 5, 1 (2000): 1-12.

Bereswill, S., et al. "Identification and Molecular Analysis of Superoxide Dismutase Isoforms in Helicobacter Pylori." FEMS Microbiol Lett 183, 2 (2000): 241-5.

Asahi, M. et al. "Helicobacter Pylori CagA Protein can be Tyrosine Phosphorylated in Gastric Epithelial Cells [see comments]." J Exp Med 191, 4 (2000): 593-602.

Logan, S. M., et al. "Functional Genomics of Helicobacter Pylori: Identification of a Beta-1, 4 Galactosyltransferase and Generation of Mutants with Altered Lipopolysaccharide." Mol Microbiol 35, 5 (2000): 1156-67.

Morl, N. et al. "Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter Pylori is Regulated by NF-kappaB in Gastric Epithelial Cancer Cells." Infect Immun 68, 4 (2000): 1806-14.

Beier, D., and R. Frank. "Molecular Characterization of Two-component Systems of Helicobacter Pylori." J Bacteriol 182, 8 (2000): 2068-76.

Faller, G., and T. Kirchner. "Role of Anti Gastric Autoantibodies in Chronic Helicobacter Pylori Infection." Microsc Res Tech 48, 6 (2000): 321-6.

Morgner, A. et al. "Gastric MALT Lymphoma and its Relationship to Helicobacter Pylori Infection: Management and Pathogenesis of the Disease." Microsc Res Tech 48, 6 (2000): 349-56.

Mittl, P. R. et al. "The Cysteine-rich Protein A from Helicobacter Pylori is a Beta-lactamase." J Bioi Chem 275, 23 (2000): 17693-9.

O'Rourke, E. J. et al. "A Novel 3-methyladenine DNA Glycosylase from Helicobacter Pylori Defines a New Class within the Endonuclease ill Family of Base Excision Repair Glycosylases." J Bioi Chem 275, 26 (2000): 20077-83.

Kuniyasu, H. et al. "Helicobacter Pylori Infection and Carcinogenesis of the Stomach." Langenbecks Arch Surg 385, 2 (2000): 69-74.

Byrd, J. C. et al. "Inhibition of Gastric Mucin Synthesis by Helicobacter Pylori." Gastroenterology 118, 6 (2000): 1072-9.

Beil, W. et al. "Role of VacA and CagA in Helicobacter Pylori Inhibition of Mucin Synthesis in Gastric Mucous Cells." J Clin Microbiol 38, 6 (2000): 2215-8.

Alm, R. A. et al. "Comparative Genomics of Helicobacter Pylori: Analysis of the Outer Membrane Protein Families." Infect Immun 68, 7 (2000): 4155-68.

Maeda, S. et al. "H. Pylori Activates NF-kappaB through a Signaling Pathway Involving LkappaB Kinases, NFkappaB-inducing Kinase, TRAF2, and TRAF6 in Gastric Cancer Cells." Gastroenterology 119, 1 (2000): 97108.

Endo, T. et al. "Cloning and Expression of Beta-1, 4-galactosyltransferase Gene from Helicobacter Pylori." Glycobiology 10, 8 (2000): 809-13.

Ebert, M. P. et al. "Molecular Alterations in Gastric Cancer: The Role of Helicobacter Pylori." Eur J Gastroenterol HepatoZ 12, 7 (2000): 795-8.

Monstein, H. J. et al. "Profiling of Bacterial Flora in Gastric Biopsies from Patients with Helicobacter Pylori-associated Gastritis and Histologically Normal Control Individuals by Temperature Gradient Gel Electropboresis and 16S rDNA Sequence Analysis." J Med Microbiol 49, 9 (2000): 817-22.

O'Toole, P. W., M. C. Lane, and S. Porwollik. "Helicobacter Pylori Motility." Microbes Infect 2, 10 (2000): 1207-14.

Enroth, H. et al. "Helicobacter Pylori Strain Types and Risk of Gastric Cancer: A Case-control Study." Cancer Epidemiol Biomarkers Prev 9, 9 (2000): 981-5.

Solaas, K. et al. "Subcellular Organization of Bile Acid Amidation in Human Liver: A Key Issue in Regulating the Biosynthesis of Bile Salts." J Lipid Res 41, 7 (2000): 1154-62.

Sodeman, T. et al. "Bile Salts Mediate Hepatocyte Apoptosis by Increasing Cell Surface Trafficking of Fas." Am J Physiol Gastrointest Liver Physiol 278, 6 (2000): G992-9.

Hirohashi, T. et al. "A TP-dependent Transport of Bile SaIts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)." J Bioi Chem 275, 4 (2000): 2905-10.

Narain, P. K., E. J. DeMaria, and D. M. Heuman. "Cholesterol Enhances Membrane-damaging Properties of Model Bile by Increasing the Intervesicular-intermixed Micellar Concentration of Hydropbobic Bile Salts." J Surg Res 84, 1 (1999): 112-9.

Nishioka, T. et al. "Partial Replacement of Bile Salts Causes Marked Changes of Cholesterol Crystallization in Supersaturated Model Bile Systems." Biochem J 340 (Pt 2) (1999): 445-51.

Stiehl, A., C. Benz, and P. Sauer. "Mechanism of Hepatoprotective Action of Bile Salts in Liver Disease." Gastroenterol Clin North Am 28, 1 (1999): 195-209, viii.

Nakajima, T. et al. "Bile Acids Increase Intracellular Ca(2+) Concentration and Nitric Oxide Production in Vascular Endothelial Cells." Br J Pharmacol 130, 7 (2000): 1457-67.

Agellon, L. B., and E. C. Torchia. "Intracellular Transport of Bile Acids." Biochim Biophys Acta 1486, 1 (2000): 198-209.

Reyes, H., and J. Sjovall. "Bile Acids and Progesterone Metabolites in Intrahepatic Cholestasis of Pregnancy." Ann Med 32, 2 (2000): 94-106.

Walters, J. R. "Bile Acids are Physiological Ligands for a Nuclear Receptor." Gut 46, 3 (2000): 308-9.

Ung, K. A. et al. "Role of Bile Acids and Bile Acid Binding Agents in Patients with Collagenous Colitis." Gut 46, 2 (2000): 170-5.

Orso, E. et al. "Transport of Lipids from Golgi to Plasma Membrane is Defective in Tangier Disease Patients and Abc1-deficient Mice." Nat Genet 24, 2 (2000): 192-6.

Roy, S. et al. "Dominant-negative Caveolin Inhibits H-Ras Function by Disrupting Cholesterol-rich Plasma Membrane Domains [see comments]." Not Cell Biol 1, 2 (1999): 98-105.

Roper, K., D. Corbeil, and W. B. Huttner. "Retention of Prominin in Microvilli Reveals Distinct Cholesterol Based Lipid Micro-domains in the Apical Plasma Membrane." Nat Cell Bioi 2, 9 (2000): 582-592.

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