MIT OpenCourseWare


Recommended Texts and Articles

Hartl, Daniel L.A Primer of Population Genetics. 3rd ed. Sunderland, MA: Sinauer Associates, 2000. ISBN: 0878933042.

Watson, James D., Tania Baker, Stephen Bell, Alexander Gann, Michael Levine, and Richard Losick. Molecular Biology of the Gene. 5th ed. San Francisco, CA: Pearson/Benjamin Cummings, 2003. ISBN: 080534635X.

Strachan, Tom, and Andrew P. Read. Human Molecular Genetics. 2nd ed. New York, NY: Wiley, 1999. ISBN: 0471330612.

Koonin, Eugene V. Galperin, and Michael Y. Norwell. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. Boston, MA: Kluwer Academic, 2003. ISBN: 1402072740.

Li, Wen-Hsiung.Molecular Evolution. Sunderland, MA: Sinauer Associates, 1997. ISBN: 0878934634.

Rice, Sean H.Evolutionary Theory: Mathematical and Conceptual Foundations. Sunderland, MA: Sinauer Associates, 2004. ISBN: 0878937021.

Felsenstein, Joseph.Inferring Phylogenies. Sunderland, MA: Sinauer Associates, 2004. ISBN: 0878931775.

Gillespie, John H.Population Genetics: A Concise Guide. 2nd ed. Baltimore, MD: Johns Hopkins University Press, 2004. ISBN: 0801880092.

Kreitman, Martin. "Methods to Detect Selection in Populations With Applications to the Human." Annu Rev Genomics Hum Genet 01 (2000): 539-59.

Suggested Papers

Gould, Stephen Jay, and Richard C. Lewontin. "The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist P." Proc Roy Soc London B 205 (1979): 581-598.

Prediction of Protein Function

Korbel, J. O., L. J. Jensen, Mering C. Von, and P. Bork. "Analysis of genomic context: Prediction of functional associations from conserved bidirect." Nat Biotechnol 22, no. 7 (July 2004): 911-7.

Pellegrini, M., E. M. Marcotte, M. J. Thompson, D. Eisenberg, and T. O. Yeates. "Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles." Proc Natl Acad Sci U.S.A. 96, no. 8 (April 13, 1999): 4285-8.

Sonnhammer, E. L., S. R. Eddy, E. Birney, A. Bateman, and R. Durbin. "Pfam: Multiple sequence alignments and HMM-profiles of protein domains." Nucleic Acids Res 26, no. 1 (January 1, 1998): 320-2.

Medical Lecture 2 (Dr. Marco Ramoni)

Hoh, J., and J. Ott. "Mathematical multi-locus approaches to localizing complex human trait genes." Nat Rev Genet 4, no. 9 (September 2003): 701-9.

Sebastiani, P., M. F. Ramoni, V. Nolan, C. T. Baldwin, and M. H. Steinberg. "Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia." Nat Genet 37, no. 4 (April 2005): 435-40.

Module 4: Functional Genomics

Turing, A. M. "The Chemical Basis of Morphogenesis Philosophical Transactions of the Royal Society of London." Series B, Biological Sciences 237, no. 641 (August 14, 1952): 37-72.

Online Resources

A Population Genetics Primer Online

Pfam Database