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教學大綱


本頁翻譯進度

燈號說明

審定:無
翻譯:李碩(簡介並寄信)
編輯:張欣茹(簡介並寄信)


概要

這門課程是針對醫學學生、生物醫學科學家、生物醫學工程師和未來的基因藥學及相關領域的指導者而開設的。將會詳細介紹生物資訊領域的最新觀點,而且不要求學生有高等數學/統計學的背景。如果需要計算,會為學生提供計算工具和從實例中獲得的相關資料。

這門課程會講到的一些問題,包括:

  • 在不遠的將來,採用新藥物和新治療方法的基因學可以帶來怎樣的實際利益?
  • 到目前為止哪些策略是最成功的?
  • 現今如何去改變診斷和治療的過程?
  • 我們的預後判斷力如何發展?
  • 如何管理大量的臨床基因資料?
  • 基因臨床試驗都包括什麼?
  • 在當今和不遠的將來,非傳統基因技術有哪些有用的特色?
  • 有多少種不同的基因資訊資源和資料庫?它們是否有用、又是如何有用?
  • 怎樣在發現研製藥物的過程中更好地利用基因資訊?
  • 將要面臨的個人及公司的倫理挑戰有哪些?
  • 我們面臨的主要侷限是什麼?

必備先修

分子生物學和現代醫學遺傳學(課程代號:HST.160)或者基礎遺傳學入門,可以運用一門程式語言(如Perl語言)或得到教師同意

課本

Brown, Terence A.《基因組》第二版,Wiley-liss,2002年6月15日,出版號0471250465

Kohane, Isaac S.、Alvin Kho及Atul J. Butte.《整體基因學的生物晶片技術》,麻省理工學院出版,2002年8月21日,出版號026211271X

Dhanda, Rahul K.《Icarus指導:公司利益下的生物倫理學問題》,第一版 Wiley-liss,2002年4月5日,出版號0471223808.

課程要求

本課程要求2次課/周(每次課90分鐘);指派3個問題集。另外,學生還被要求做一次20分鐘的口頭報告和一份完整的科學論文,要達到能發表的水準,長度為10頁左右。


Overview

This course is targeted to medical students, biomedical scientists, biomedical engineers, and instructors of future genomic medicine and related courses. Advanced concepts in the bioinformatics field will be carefully introduced and require no advanced math/statistics background. Where computation is needed, the students will be provided with working tools and relevant data sets from real world examples.

Some of the questions addressed in the course include:

  • What real benefits of genomics can be anticipated in the near future in terms of new drugs and treatments?
  • Which strategies to date have been the most successful?
  • How can diagnosis and the diagnostic process be changed today?
  • How do our prognostic abilities change?
  • How does one manage the deluge of clinically relevant genomic data?
  • What constitutes a genomic clinical trial?
  • What are the useful features of alternative genomic technologies today and for the near future?
  • What are the different kinds of genomic informational resources and databases? Are they useful and how?
  • How can the drug discovery process make better use of genomic information?
  • What are the ethical individual and corporate challenges ahead?
  • What are the key limitations we face?

Pre-requisites

Molecular Biology and Genetics in Modern Medicine (HST.160) or basic introductory genetics, facility with a programming language (e.g., Perl), or instructor's permission.

Texts

Brown, Terence A. Genomes. 2nd ed. Wiley-Liss, June 15, 2002. ISBN: 0471250465.

Kohane, Isaac S., Alvin Kho, and Atul J. Butte. Microarrays for an Integrative Genomics. MIT Press, August 21, 2002. ISBN: 026211271X.

Dhanda, Rahul K. Guiding Icarus: Merging Bioethics with Corporate Interests. 1st ed. Wiley-Liss, April 5, 2002. ISBN: 0471223808.

Course Requirements

Course meets for 2 lectures/week (1.5 hours/lecture); 3 problem sets assigned. In addition, students are required to give a 20-minute oral presentation and complete a scientific, publication-quality paper, approximately 10 pages long.


 
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