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I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures
1 Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms Prof. Spector
2 Tissue Structures and Unit Cell Processes Prof. Spector
3 Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins Prof. Spector
4 Models for the Mechanical Behavior of Porous Scaffolds Prof. L. Gibson Homework 1 due
5 Structure-Properties Relationships for Tissues Prof. Spector
6 Mechanics of Selected Tissues Prof. S. Socrate
II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation
7 Effects of Exogenous Mechanical Forces on Cells Prof. Spector Homework 2 due
8 Response of Cells to Substrate Strain Prof. Spector
9 Endothelial Cell Response to Flow Prof. C. F. Dewey
10 Quiz 1
11 Measuring Cell Contraction

Cell Force Monitor
Brendan Harley
12 Endogenous Mechanical Force Generation by Cells Prof. Spector
13 Models for Cell Contraction In Vitro and In Vivo Prof. Spector
14 Mechanical Coupling of Cells with Matrix Prof. Yannas
15 Cell-matrix Interactions During Wound Closure Prof. Yannas
16 Blockade of Contraction During Induced Organ Regeneration Prof. Yannas
17 Review Prof. Spector
18 Quiz 2
III. Tissue Mechanics
19 Review of Principles of Linear Elastic Mechanics Prof. Yannas
20 Nonlinear Elasticity: Tendon and Skin Prof. Yannas
21 Linear Viscoelastic Behavior Prof. Yannas
22 Response of Articular Cartilage to Mechanical Loading Prof. A. Grodzinsky
23 Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc Prof. Spector
24 Mechanical Behavior of Bone Prof. Spector Homework 3 due
25 Response of Bone to Mechanical Loading

Prof. Spector
26 Quiz 3

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