MIT OpenCourseWare


Part I. Principles of Tissue Engineering: Scaffolds and Cells
1 Course Overview/Clinical Problems for Tissue Engineering Solution

Introduction to Tissue Engineering in China (PDF)

Scaffolds: Introduction (PDF)

Scaffolds: Collagen-GAG Analogs of Extracellular Matrix (PDF) (Courtesy of Prof. Yannas. Used with permission.)
Prof. Spector, MIT / Prof. Cui, Tsinghua University

Prof. Cui, Tsinghua University

Prof. Spector, MIT

Prof. Yannas, MIT
2 Cells: Liver Cells (PDF) (Courtesy of Yingxin Xu and Qingling Feng. Used with permission.)

Scaffolds: Recent Advances in Tissue Engineering
Yingxin Xu, M. D., and Qingling Feng Ph. D., Tsinghua University

Prof. Langer, MIT
3 Scaffolds: Free-Form Manufacturing (PDF 1 of 2 - 2.6 MB)(PDF 2 of 2 - 1.8 MB) (Courtesy of Prof. Yongnian Yan. Used with permission.)

Scaffolds: Self-Assembled Proteins (PDF - 1.2 MB) (Courtesy of Dr. Shuguang Zhang. Used with permission.)

Review (PDF)
Prof. Yan, Tsinghua University

Dr. S. Zhang, MIT

Prof. Spector, MIT
4 Cells: Sources

Cells: Differentiated versus Stem Cells (PDF)
Dr. C. Vacanti, MIT

Prof. Spector, MIT
Part II. Principles of Tissue Engineering: Cells and Regulators
5 Scaffolds: Biomimetics Design (PDF)

Cells: Effects of Culture Conditions (PDF) (Courtesy of Dr. Lisa Freed. Used with permission.)

Review (PDF - 1.4 MB)
Prof. Cui, Tsinghua University

Dr. L. Freed, MIT

Prof. Spector, MIT
6 Quiz 1
7 Regulators: Response to Mechanical Loading

Regulators: Roles of Environmental Factors
Prof. Grodzinsky, MIT

Dr. Vunjak-Novakovic, MIT
8 Cells: Embryonic and Other Stem Cell for Tissue Engineering

Gene Therapy

Regulators: Gene Transfer Wedded to Tissue Engineering (PDF) (Courtesy of Prof. Chris Evans. Used with permission.)
Prof. Guo, Tsinghua University

Dr. Zhijie Chang, Tsinghua University

Prof. C. Evans, Harvard Medical School
Part III. Practice of Tissue Engineering: Clinical Applications
9 Applications: Skin and Peripheral Nerve Regeneration (PDF - 1.0 MB) (Courtesy of Prof. Yannas. Used with permission.)

Nerve Repair (PDF - 1.3 MB) (Courtesy of Xiufang Zhang, Nanming Zhao, and Yandao Gong. Used with permission.)

Discussion: Clinical Applications (PDF)
Prof. Yannas, MIT

Xiufang Zhang, Nanming Zhao, Yandao Gong, Tsinghua University

Prof. Spector, MIT
10 Blood Vessels

Heart Valves

Discussion: Comparative Analysis of Tissue Engineering Strategies (PDF)
Prof. Schoen, Harvard Medical School

Dr. W. B. Li, Tsinghua University

Prof. Spector, MIT
11 Urinary Tissues/Organs

Clinical Applications and Underlying Principles
Prof. Atala, MIT

Prof. Y. Cao, Tsinghua University
12 Bone Regeneration (PDF) (Courtesy of Yu Xing M. D., Ph. D. Used with permission.)

Cartilage Repair (PDF - 1.0 MB)

Discussion: Review (PDF)
Dr. Yu Xing, Tsinghua University, and Prof. Yan Wang, M. D., General Hospital of Peoples' Liberation Army

Prof. Spector, MIT

Prof. Spector, MIT
13 Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries (PDF)

Brain Repair

Prof. Spector, MIT

Prof. Cui, Tsinghua University

Prof. Spector, MIT / Prof. Cui, Tsinghua University
14 Quiz 2