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課程單元 實驗 討論 重要日期
概論
Overview
1 課程介紹,介紹功能性磁振造影
Introduction to Course
Introduction to Functional Magnetic Resonance Imaging
安全性與人體實驗課題,第一部份: 人體實驗注意事項
Safety and Human Subjects Issues, pt. 1
Notes on Human Subjects
功能性神經系統
Functional Neural Systems
2 神經系統及神經信號處理概論
Overview of Neural Systems
Neural Signal Processing
介紹實驗課程、觀看核磁共振影像以及使用MATLAB®
Introduction to Lab, Viewing MR Images, and MATLAB®
發作業問題 #1
Hand out Problem Set #1
3 視覺系統,體感覺及運動系統
Visual System
Somatosensory and Motor Systems
腦如何處理視覺訊息:來自神經造影的洞見與爭議 (Kanwisher & Haxby 的論文)
How the Brain Processes Visual Information, Insights & Controversies from Neuroimaging Studies (Kanwisher & Haxby papers)
4 記憶系統,注意力、動機、情緒
Memory Systems
Attention, Motivation, Emotion
實驗1:介紹功能性磁振造影資料擷取,第一部份:擷取
LAB 1: Introduction to fMRI Data Acquisition, Part 1- Acquisition
造影生理學
Imaging Physiology
5 造影生理學概論
Overview of Imaging Physiology
應用呼吸與心血管生理學(一)
Applied Respiratory and Cardiovascular Physiology I
神經活化與腦血流改變之連結(Iadecola & Mintun的論文)
Coupling Between Neural Activity and CBF Changes (Iadecola & Mintun papers)
交作業問題#1
Problem Set #1 Due
6 應用呼吸與心血管生理學(二)
Applied Respiratory and Cardiovascular Physiology II
生理雜訊對分析與解釋功能性磁振造影的影響
Impact of Physiological Noise on Analysis and Interpretation of fMRI Data
發作業問題#2
Hand out Problem Set #2
7 腦血管解剖學與中樞神經系統血流之神經調控
Cerebrovascular Anatomy and Neural Regulation of CNS Blood Flow
實驗1:介紹功能性磁振造影資料擷取,第一部份:分析
LAB 1: Introduction to fMRI Data Acquisition, Part 2- Analysis
8 腦血流與代謝之整體與局部特定改變的神經血管連結
Neurovascular Coupling
Global vs Regionally Specific Changes in CBF and Metabolism
功能性磁振造影資料的空間定位性—與其他神經科學資料相比較(Veltman & Disbrow論文)
Localization in fMRI Data Sets - Comparison with Other Types of Neuroscience Data (Veltman & Disbrow papers)
影像擷取物理學
Physics of Image Acquisition
9 結構與功能性磁振造影信號擷取概論
Overview of Structural and functional MRI Signal Acquisition
實驗2:功能性磁振造影信號的生物物理,第一部份:擷取
LAB 2: Biophysical Basis of fMRI Signals, Part 1- Acquisition
發作業問題#3,交實驗報告#1
Hand out Problem Set #3
Lab Report #1 Due
10 核磁共振信號:磁化向量、激發、偵測、核磁共振信號、訊噪比,觀察核磁共振信號:核磁共振量測、T2*、T2、梯度、梯度迴訊、自旋迴訊
The NMR Signal: Magnetization, Excitation, Detection, NMR Signal, SNR
Monitoring the NMR Signal: NMR Measurements, T2*, T2, Gradients, Gradient-echo, Spin-echo
核磁共振信號偵測、相位陣列接收線圈
MR Signal Detection, Phased Array Receiver Coils
交作業問題#2
Problem Set #2 Due
11 磁振造影:核磁共振信號頻率之空間編碼、切面與相位編碼、自旋彎曲,快速磁振造影基礎k空間、快速成像、影像扭曲
MRI: Spatially Encoding the NMR Signal Frequency, Slice and Phase Encoding, Spin Warp
Basics of Fast MRI K-space, Fast Imaging, Distortions
平行造影影像擷取方法
Parallel Image Acquisition Strategies
12 複習:空間編碼、k空間,磁振造影影像對比:T1, T2, T2*, 擴散
Review: Spatial Encoding, K-space
MonRI Contrasts: T1,T2,T2*, Diffusion
實驗2:功能性磁振造影信號的生物物理,第二部份:分析
LAB 2: Biophysical Basis of fMRI Signals, Part 2- Analysis
13 血氧濃度變化對比(第一部份):血液動態反應、時間、空間解析度,運用生理數據強化功能性磁振造影信號偵測
BOLD Contrast (part 1) Hemodynamic Response, Temporal, Spatial Resolution
Improving fMRI Signal Detection Using Physiological Data
時間及空間解析度(如:Logothetis在『神經元』(Neuron)及『自然』(Nature)期刊的文章)
Temporal and Spatial Resolution (e.g. New Logothetis Articles in Neuron and Nature)
14 血氧濃度變化對比(第二部份):生理雜訊、磁場強度血氧濃度變化以外的方法,血氧濃度變化之回顧、微灌流跟血氧濃度變化之比較、動脈標記法(Arterial Spin Labeling)、腦血容積
BOLD Contrast (part 2) Physiological Noise, Field Strength
Alternatives to BOLD Review of BOLD, Perfusion vs BOLD, Arterial Spin Labelling, Cerebral Blood Volume
實驗3:運用集中掃瞄法及心跳同步來偵測聽覺區活化與腦幹信號
LAB 3: Clustered Volume Acquisition (CVA) & Cardiac Gating Techniques for Detection of Auditory Activation and Brainstem Signals Lab
交實驗報告#2
Lab Report #2 Due
15 擴散影像之物理原理,微灌流影像之物理原理及臨床應用
Physics of Diffusion Weighted Imaging
Physics and Clinical Applications of Perfusion Weighted Imaging
動脈標記法(Wong的論文)
ASL (Wong Paper)
交作業問題#3
Problem Set #3 Due
16 功能性磁振造影之量化,腦血容積、腦微灌流與動脈標記法
Quantitative fMRI
CBV, CBF & ASL
實驗4:擴散梯度實驗
LAB 4: Diffusion Gradients Lab
交實驗報告#3
Lab Report #3 Due
17 期中考
Mid-term Exam
安全性與人體實驗課題,第二部份:倫理
Safety and Human Subjects Issues, pt. 2. Ethics Module
實驗設計
Experiment Design
18 實驗設計一般原理:第一部份
General Principles of Experimental Design, pt. 1
實驗設計(Manoach與Stark的論文)
Paradigm Design (Manoach and Stark)
發作業問題#4,交實驗報告#4
Hand out Problem Set #4
Lab Report #4 Due
19 實驗設計一般原理:第二部份造影時的心理狀態變項
General Principles of Experimental Design, pt. 2
Psychological State Variables in Imaging
實驗5:功能性磁振造影資料之統計分析
LAB 5: Statistical Analysis of fMRI Data
統計分析
Statistical Analysis
20 功能性磁振造影統計分析概論,介紹功能性磁振造影資料之單變量分析—第一部份,機率,統計
Overview of fMRI Statistical Analysis
Introduction to Univariate Analysis of fMRI Data - Part 1 Probability Notes
Statistics Notes
複習統計推論原理
Review of Principles of Statistical Inference
交作業問題#4
Problem Set #4 Due
21 介紹功能性磁振造影資料之單變量分析—第二部份
Introduction to Univariate Analysis of fMRI Data - Part 2
實驗5:功能性磁振造影資料之統計分析
LAB 5: Statistical Analysis of fMRI Data
發作業問題#5
Hand out Problem Set #5
22 功能性磁振造影資料之多變量統計分析方法,群體分析
Multivariate Statistical Approaches to fMRI Data Analysis
Group Analysis of fMRI Data
交實驗報告#5
Lab Report #5 Due
23 為功能性磁振造影資料建立新的統計模式
Building New Statistical Models for fMRI Data
實驗6:形態分割
LAB 6: Morphometric Segmentation
24 功能性磁振造影實驗設計之統計效率
Statistical Efficiency in fMRI Paradigm Design
統計問與答
Statistics Q'&'A
交作業問題#5
Problem Set #5 Due
結構分析
Structural Analysis
25 以表面為基礎的解剖構造分析
Surface Based Anatomical Analysis
實驗7:課程回顧
LAB 7: Course Review (REQUIRED)
交實驗報告#6
Lab Report #6 Due
26 解剖構造分析之空間標準化,擴散張量影像在臨床及基礎神經科學之應用
Spatial Normalization for Anatomic Analysis
Clinical and Basic Neuroscience Applications of Diffusion Tensor Imaging
何謂基準點(討論Squire的論文)
What is Baseline (discussion of Squire paper)
27 期末考
Final Exam

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