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教學大綱


本頁翻譯進度

燈號說明

審定:無
翻譯:施懿恩(簡介並寄信)
編輯:陳玉侖(簡介並寄信)

教學目標

放射線與生物物質之交互作用為本課程中心主題。本課程欲提供廣泛知識以了解不同輻射線如何釋放能量,包括次級輻射的產生和表現、輻射線如何影響細胞、不同輻射線為何有非常不同型態的生物效應。其它主題包括:輻射對生物系統(含DNA傷害、體外細胞生存模組、哺乳動物系統)的影響。課程含蓋放射治療、輻射症侯群,致癌機轉,另提及地球和外太空的放射源及輻射保護相關事宜。課程中會以最新的文獻中的例子作為補充講解。

成績評分方式

在學期中有6個作業及2次的測驗。所有的學生須完成一個以相關課程為主題的學期報告。當然我們會提供相關主題清單,但是同學仍可自行決定主題。最後以完成學期報告的口頭呈現。所有同學都必須根據個人學期報告做口頭報告,本課程沒有期末考試。

評分將分為下列部份:

活動 佔總分比例
作業 30%
測驗 40%
學期報告及口頭報告 30%


指定教科書

Hall, Eric J.《給放射科相關醫師的輻射生物學》 第五版. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 0781726429
(台灣讀者可洽藝軒圖書公司購書)

額外參考書目:

Turner, J. E.《原子、輻射、輻射防護措施》 第二版. New York: J. Wiley, 1995. ISBN: 0471595810.

Tubiana, M., J. Dutreix, 和 A. Wambersie.《輻射生物學入門》 London, New York, Philadelphia: Taylor and Francis, 1990. ISBN: 0850667453.

Alpen, Edward L. 《輻射生物物理學》. 第二版. San Diego: Academic Press, 1998. ISBN: 0120530856.

Zipursky, Matsudaira, Baltimore, 和 Darnell.《分子生物學》,第四版. New York: W.H. Freeman and Company, 2000. ISBN: 0716743663.Lodish, Berk,
Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell. Molecular Cell Biology. 4th ed. New York: W.H. Freeman and Company, 2000. ISBN: 0716743663.


Objectives

The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture material.

Grading

There will be about 6 problem sets over the course of the semester. There will be two exams. All students are required to write a term paper on a topic related to the subjects covered in this course. A list of possible topics will be provided, but students are free to choose their own topic. All students are required to give an oral presentation on their term paper topic. There will be no final exam.

Grading will be divided as follows:

ACTIVITIES PERCENTAGES
Problem Sets 30%
Exams 40%
Term Paper and Presentation 30%


Textbook

Hall, Eric J. Radiobiology for the Radiologist. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 0781726429.

Additional References

Turner, J. E. Atoms, Radiation, and Radiation Protection. 2nd ed. New York: J. Wiley, 1995. ISBN: 0471595810.

Tubiana, M., J. Dutreix, and A. Wambersie. Introduction to Radiobiology. London, New York, Philadelphia: Taylor and Francis, 1990. ISBN: 0850667453.

Alpen, Edward L. Radiation Biophysics. 2nd ed. San Diego: Academic Press, 1998. ISBN: 0120530856.

Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell. Molecular Cell Biology. 4th ed. New York: W.H. Freeman and Company, 2000. ISBN: 0716743663.


 
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