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本頁翻譯進度

燈號說明

審定:無
翻譯:嘉翎(簡介並寄信)
編輯:許馨文(簡介並寄信)


綱要

本課程目的為使學生對於遺傳及生化網路上的生物性功能有計量上的了解。也將會提供學生建構網路組件的必須數學工具,如生物開關、震盪儀、過濾器、放大器等。成功利用系統生物學處理的一系列生物問題範例,將由探討近期相關文獻的方式加以介紹。本課程潛在的挑戰是學生們多半來自不同的背景。必要時請自行研讀相關的生物或數學資料。熟讀課程中的問題討論可以幫助你填補不足的知識缺空,以及幫助你準備相關作業。

本課程共分成三大部分:

  • I 系統為生物學(14堂)將細胞視成一個完全攪拌反應器
  • II 系統細胞生物學(8堂)將細胞視成一個既有濃度梯度的分隔系統
  • III 系統發育生物學(3堂)在社會脈絡中細胞間的信息溝通

教科書

課程講義為主。以下推薦兩本優良生物參考書:

Bruce Alberts等著,《細胞分子生物學》,第四版,New York: Garland Science, 2002.。

Harvey Lodish 等著,《分子細胞生物學》,第五版,New York: W. H. Freeman and Company, 2004。
(譯註:以上兩本皆有中譯本。)

作業、考試及成績

本課程會時常使用MATLAB®作為必需解題工具。請確定你已經明白或學會如何使用。

本課程共有五個題組,期末題組發放自行帶回去做。分數分配如下:

作業 百分比
題組一 15%
題組二 15%
題組三 15%
題組四 15%
題組五 15%
期末考 25%



Overview

The goal of this course is to help students develop a quantitative understanding of the biological function of genetic and biochemical networks. Students will be provided with the essential mathematical tools needed to model network modules, such as biological switches, oscillators, filters, amplifiers, etc. An array of example biological problems that can be successfully tackled with a systems biology approach will be introduced by discussing recent papers on the subject. The intrinsic challenge of this class is that students are coming in with wildly different backgrounds. Read up on your biology or math if needed. Use time in the recitations to help close some of the knowledge gaps and to help you prepare for the homework.

There are three levels of complexity to Systems Biology:

  • I Systems Microbiology (14 Lectures) 'The cell as a well-stirred biochemical reactor'
  • II Systems Cell Biology (8 Lectures) 'The cell as a compartmentalized system with concentration gradients'
  • III Systems Developmental Biology (3 Lectures) 'The cell in a social context communicating with neighboring cells'

Text

The course notes serve as the text. For good biology reference texts, see:

Alberts, Bruce, et. al. Molecular Biology of the Cell. 4th ed. New York: Garland Science, 2002. ISBN: 0815332181.

Lodish, Harvey, et al. Molecular Cell Biology. 5th ed. New York: W. H. Freeman and Company, 2004. ISBN: 0716743663.

Assignments, Exams, and Grading

MATLAB® will be used intensively during the course. Make sure you know or learn how to use it as it is necessary for the problem sets.

There are 5 problem sets and one take home final for the course. The grading breakdown is as follows:

Assignments PERCENTAGES
Problem set 1 15%
Problem set 2 15%
Problem set 3 15%
Problem set 4 15%
Problem set 5 15%
Final 25%

 
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